What is a temperate phage (lysogenic phages)?

lysogenic cycle of bacteriophages
lysogenic cycle

A bacteriophage that displays lysogenic life cycle in contrast to virulent phage that does not have the ability to display lysogeny (especially following mutation). Many temperate phages are capable of integrating their genome into the genome of their host. These phages can infect bacterial cell but rarely cause lysis. Temperate phages can sometimes be referred as lysogenic or non virulent phages.

Can lysogenic phages cause cell lysis?

Under certain conditions lysogenic phages can be induced to follow a lytic cycle. Most researches suggest that when the host cell is subjected under stresses can result into activation activity of lytic bacteriophages.

What is a typical characteristic of a temperate phage plaque?

All of the phage isolates formed turbid plaques on the bacterial host lawns, and turbid plaques are the typical plaque morphology of temperate phages

Which type of phage lytic or temperate is a better candidate for phage therapy?

the lytic phages are most suitable for phage therapy, based on their broad host range, high virulence, short lysis period and given that they encode no known toxin or antimicrobial resistance genes. Some studies suggested that lysogenic phages is responsible for eliciting the immune response although more research is needed to be done to pin point any advantage that can be utilized in PT.

What are the similarities between lytic and lysogenic cycle?

  • Both are mechanisms of viral reproduction.
  • They take place within the host cell.
  • The cycles produce thousands of copies of the original virus.
  • Both lytic and lysogenic can moderate the DNA replication and the protein synthesis of the host cell.

Temperate bacteriophages display a lysogenic life cycle, which requires them to integrate their viral genome into the bacterial chromosome.

Raphael Hans

Young scientist, phage enthusiast, and passionate about driving the development of bacteriophage therapy and application. Working as a research assistant at Makerere University.

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