What is a temperate phage (lysogenic phages)?

lysogenic cycle of bacteriophages
lysogenic cycle

Template phage

A bacteriophage has a lysogenic life cycle, as opposed to a virulent phage, which does not have lysogeny (especially following mutation). Many temperate phages can integrate their genome into the host's genome. These phages have the ability to infect bacterial cells but rarely cause lysis. Temperate phages are also known as lysogenic or nonvirulent phages.

Can lysogenic phages cause cell lysis?

Lysogenic phages can be induced to enter a lytic cycle under certain conditions. Most studies suggest that when the host cell is stressed, the activation activity of the lytic cycle occurs.

What is a typical characteristic of a temperate phage plaque?

If it infects a rapidly growing cell population, it produces a plaque with a "bulls-eye" plaque morphology, with a turbid center surrounded by a ring of the clearing.

Which phage lytic or temperate type is a better candidate for phage therapy?

The lytic phages are most suitable for phage therapy based on their broad host range, high virulence, and short lysis period, and given that they encode no known toxin or antimicrobial resistance genes. Lysogenic phages, according to some research, are responsible for eliciting an immune response. As a result, it can be used for other purposes in the biotechnology industry. More research is needed, however, to identify any advantages that can be used in PT.

What are the similarities between the lytic and lysogenic cycles?

  • Both are mechanisms of viral reproduction.
  • They take place within the host cell.
  • The cycles produce thousands of copies of the original virus.
  • Both lytic and lysogenic can moderate the DNA replication and the protein synthesis of the host cell.
Temperate bacteriophages have a lysogenic life cycle, which requires the viral genome to be incorporated into the bacterial chromosome. This is how bacteriophage DNA is transferred without the infected cell being killed.

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